- 作者：Mikaela B. von Bonsdorff ; Danielle A.I. Groffen ; Jean-Sebastien Vidal ; Taina Rantanen ; Palmi V. Jonsson ; Melissa Garcia ; Thor Aspelund ; Gudny Eiriksdottir ; Kristin Siggeirsd¨®ttir ; Lenore Launer ; Vilmundur Gudnason ; Tamara B. Harris ; For the Age ; Gene/Environment Susceptibility-Reykjavik Study Investigators
- 关键词：Atherosclerosis ; Coronary artery calcification ; Cardiovascular disease risk factors ; Aging ; Mortality ; Epidemiology
- 刊名：International Journal of Cardiology
- 出版年：2013
- 出版时间：3 October, 2013
- 年：2013
- 卷：168
- 期：3
- 页码：2094-2099
- 全文大小：406 K
Background
Coronary artery calcium (CAC) and physical performance have been shown to be associated with mortality, but it is not clear whether one of them modifies the association. We investigated the association between the extent of CAC and physical performance among older individuals and explored these individual and combined effects on cardiovascular disease (CVD) mortality and non-CVD mortality.Methods
We studied 4074 participants of the AGES-Reykjavik Study who were free from coronary heart disease, had a CAC score calculated from computed tomography scans and had data on mobility limitations and gait speed at baseline in 2002-2006 at a mean age of 76 years. Register-based mortality was available until 2009.
Results
Odds for mobility limitation and slow gait increased according to the extent of CAC. Altogether 645 persons died during the follow-up. High CAC, mobility limitation and slow gait were independent predictors of CVD mortality and non-CVD mortality. The joint effect of CAC and gait speed on non-CVD mortality was synergistic, i.e. compared to having low CAC and normal gait, the joint effect of high CAC and slow gait exceeded the additive effect of these individual exposures on non-CVD mortality. For CVD mortality, the effect was additive i.e. the joint effect of high CAC and slow gait did not exceed the sum of the individual exposures.
Conclusions
The extent of CAC and decreased physical performance were independent predictors of mortality and the joint presence of these risk factors increased the risk of non-CVD mortality above and beyond the individual effects.