Structure of a Chaperone-Usher Pilus Reveals the Molecular Basis of Rod Uncoiling
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- 作者：Manuela K. Hospenthal1 ; Adam Redzej1 ; Karen Dodson3 ; Marta Ukleja1 ; Brandon Frenz2 ; Catarina Rodrigues1 ; Scott J. Hultgren3 ; Frank DiMaio2 ; Edward H. Egelman4 ; egelman@virginia.edu" class="auth_mail" title="E-mail the corresponding author ; Gabriel Waksman1 ; g.waksman@mail.cryst.bbk.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell
- 出版年：2016
- 出版时间：14 January 2016
- 年：2016
- 卷：164
- 期：1-2
- 页码：269-278
- 全文大小：3910 K
文摘
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The atomic structure of a chaperone-usher pilus rod was solved by cryo-EM
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Each subunit makes contact with five preceding and five succeeding subunits
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Mutations at subunit-subunit interfaces affect rod formation, not polymerization
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The structure elucidates the molecular basis for rod uncoiling