Proteomics of Primary Cilia by Proximity Labeling
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- 作者：David U. Mick1 ; Rachel B. Rodrigues2 ; Ryan D. Leib3 ; Christopher M. Adams3 ; Allis S. Chien3 ; Steven P. Gygi2 ; Maxence V. Nachury1 ; nachury@stanford.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Developmental Cell
- 出版年：2015
- 出版时间：23 November 2015
- 年：2015
- 卷：35
- 期：4
- 页码：497-512
- 全文大小：7784 K
文摘
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APEX labeling enables proteomic analyses of a non-membrane-enclosed compartment
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Cilia-APEX identifies the kinases PKA, AMPK, and LKB1 in primary cilia
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PKA functions inside cilia to phosphorylate GLI3 and regulate Hedgehog signaling
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Proteomic profiling of Ift27/Bbs19 cilia detects ciliary accumulation of BBSome