Effect of Alpinia officinarum Hance alcohol extracts on primary dysmenorrheal

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• 作者：Ling Huang ; Jun-Qing Zhang ; You-Bin Li ; Mi Liu ; Hui-Ming Deng ; Yu-Chao Luo ; Yin-Feng Tan ; Jie Hou ; Gui-Wei Yao ; Wei-Wei Guan ; ^{puer6@163.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Alpinia officinarum Hance alcohol extracts ; Relieve ; Primary dysmenorrhea
• 刊名：Asian Pacific Journal of Tropical Medicine
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：9
• 期：9
• 页码：882-886
• 全文大小：293 K

文摘

To study the effect of Alpinia officinarum Hance (A. officinarum) 80% alcohol extract on the primary dysmenorrhea.

Methods

A. officinarum 80% alcohol extract were enriched by macroporous adsorption resins. Female mice of primary dysmenorrhea model were established by oxytocin induction; the effects of A. officinarum 80% alcohol extract on primary dysmenorrhea were observed by body twist method; and the homogenate level of prostaglandin F_2α (PGF_2α), prostaglandin E₂ (PGE₂) and Ca²⁺ in the uterus were observed in oxytocin-induced female mice.

Results

The writhing frequency of primary dysmenorrhea mice was significantly decreased after treatment of A. officinarum 80% alcohol extract and the level of PGF_2α, PGE₂ and Ca²⁺ in mice uterus was significantly decreased (P < 0.05, P < 0.01) in groups of mice treated with middle and high dosage of A. officinarum 80% alcohol extract compared with that of model group.

Conclusions

These findings suggest that A. Officinarum 80% alcohol extract can significantly relieve primary dysmenorrhea.