Timing the Drosophila Mid-Blastula Transition: A Cell Cycle-Centered View

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• 作者：Kai Yuan¹ ; Charles A. Seller¹ ; Antony W. Shermoen¹ ; Patrick H. O&rsquo ; Farrell¹ ; ^{ofarrell@cgl.ucsf.edu" class="auth_mail" title="E-mail the corresponding author}
• 关键词：cyclin ; Cdk1 ; Cdc25 ; S phase checkpoint ; DNA replication ; mid-blastula transition (MBT)
• 刊名：Trends in Genetics
• 出版年：2016
• 出版时间：August 2016
• 年：2016
• 卷：32
• 期：8
• 页码：496-507
• 全文大小：1903 K

文摘

At the mid-blastula transition (MBT), externally developing embryos refocus from increasing cell number to elaboration of the body plan. Studies in Drosophila reveal a sequence of changes in regulators of Cyclin:Cdk1 that increasingly restricts the activity of this cell cycle kinase to slow cell cycles during early embryogenesis. By reviewing these events, we provide an outline of the mechanisms slowing the cell cycle at and around the time of MBT. The perspectives developed should provide a guiding paradigm for the study of other MBT changes as the embryo transits from maternal control to a regulatory program centered on the expression of zygotic genes.