A novel indigoid anti-tuberculosis agent
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- 作者：Larry L. Klein ; Valentina Petukhova ; Baojie Wan ; Yuehong Wang ; Bernard D. Santasiero ; David C. Lankin ; Guido F. Pauli ; Scott G. Franzblau
- 关键词：Anti-tuberculosis ; Indigoid ; X-ray
- 刊名：Bioorganic and Medicinal Chemistry Letters
- 出版年：1 January, 2014
- 年：2014
- 卷：24
- 期：1
- 页码：268-270
- 全文大小：656 K
文摘
The structure of a novel indigoid component was characterized by X-ray crystallography. This compound exhibited excellent anti-tuberculosis activity against Mycobacterium tuberculosis H37Rv in whole cell culture showing a submicromolar minimum inhibitory concentration (MIC). A synthesis of this molecule was designed and carried out to produce sufficient material for further testing. The in vitro profile, structure, and first synthesis of this indigoid component is reported.