文摘
NR mRNA expression and function is similar between organoids and respective tissues. Fxrα, Lxrα/β, Pparα/γ activation showed induction of multiple target genes. NR target genes were induced in WT, but not in NR −/− organoids. Organoids are easy to use and suitable to study NR biology and targetability. Trpm6, Slc26a3, Ang1, and Rnase4 are novel target genes of Fxr in the intestine.