Bisphosphonates Target B Cells to Enhance Humoral Immune Responses

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• 作者：Elena Tonti ; Nereida Jim茅nez聽de聽Oya ; Gabriele Galliverti ; E.聽Ashley Moseman ; Pietro Di聽Lucia ; Angelo Amabile ; Stefano Sammicheli ; Marco De聽Giovanni ; Laura Sironi ; Nicolas Chevrier ; Giovanni Sitia ; Luigi Gennari ; Luca聽G. Guidotti ; Ulrich聽H. von聽Andrian ; Matteo Iannacone
• 刊名：Cell Reports
• 出版年：31 October, 2013
• 年：2013
• 卷：5
• 期：2
• 页码：323-330
• 全文大小：535 K

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Summary

Bisphosphonates are a class of drugs that are widely used to inhibit loss of bone mass in patients. We show here that the administration of clinically relevant doses of bisphosphonates in mice increases antibody responses to live and inactive viruses, proteins, haptens, and existing commercial vaccine formulations. Bisphosphonates exert this adjuvant-like activity in the absence of CD4⁺ and 纬未 T聽cells, neutrophils, or dendritic cells, and their effect does not rely on local macrophage depletion, Toll-like receptor signaling, or the inflammasome. Rather, bisphosphonates target directly B cells and enhance B cell expansion and antibody production upon antigen encounter. These data establish bisphosphonates as an additional class of adjuvants that boost humoral immune responses.