Intrinsic facilitation of adult peripheral nerve regeneration by the Sonic hedgehog morphogen
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- 作者：Jose A. Martinezc ; Masaki Kobayashia ; Anand Krishnana ; Christine Webberb ; Kimberly Christiec ; GuiFang Guoc ; Vandana Singhc ; Douglas W. Zochodnea ; zochodne@ualberta.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：Peripheral nerve ; Regeneration ; Sonic hedgehog protein ; Nerve injury
- 刊名：Experimental Neurology
- 出版年：2015
- 出版时间：September 2015
- 年：2015
- 卷：271
- 期：Complete
- 页码：493-505
- 全文大小：2585 K
文摘
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Sonic hedgehog protein (Shh), a developmental morphogen, is expressed in the PNS.
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Shh knockdown attenuates neurite outgrowth and branching of adult sensory neurons.
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Shh knockdown reduces regrowth from transected peripheral nerves.
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Shh is an intrinsic facilitator of axon outgrowth in the adult PNS.