Evaluation of genipin-crosslinked chitosan hydrogels as a potential carrier for silver sulfadiazine nanocrystals
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- 作者：Lei Gaoa ; b ; Hui Gana ; Zhiyun Menga ; Ruolan Gua ; Zhuona Wua ; Xiaoxia Zhua ; Wenzhong Suna ; Jian Lia ; Ying Zhenga ; Tao Sunc ; Guifang Doua ; douguifang@vip.163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Silver sulfadiazine ; Chitosan ; Hydrogel ; Antibacterial ; Wound healing
- 刊名：Colloids and Surfaces B: Biointerfaces
- 出版年：2016
- 出版时间：1 December 2016
- 年：2016
- 卷：148
- 期：Complete
- 页码：343-353
- 全文大小：2067 K
文摘
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AgSD nanocrystals improved the dissolution behavior but aggravate the cytotoxicty.
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Encapsulation of AgSD nanocrystals in chitosan hydrogels reduced their cytotoxicity.
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Encapsulation of AgSD nanocrystals in hydrogels facilitated sustained release.
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Encapsulation of AgSD nanocrystals in hydrogels remained high antibacterial activity.
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Hydrogels containing AgSD nanocrystals showed the best in vivo healing effects.