A?ai (Euterpe oleracea Mart.) feeding attenuates dimethylhydrazine-induced rat colon carcinogenesis
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- 作者：Mariana F. Fragoso ; Guilherme R. Romualdo ; Daniel A. Ribeiro ; Luis F. Barbisan
- 关键词：Aberrant crypt foci ; Spray-dry ; Aç ; aí ; pulp ; Colon carcinogenesis
- 刊名：Food and Chemical Toxicology
- 出版年：2013
- 出版时间：August, 2013
- 年：2013
- 卷：58
- 期：Complete
- 页码：68-76
- 全文大小：1681 K
文摘
This study investigated the protective effect of spray-dried a?a¨ª powder (AP) intake on colon carcinogenesis induced by 1,2-dimethylhydrazine (DMH) in male Wistar rats. After 4 weeks of DMH administrations, the groups were fed with standard diet, a diet containing 2.5 % or 5.0 % AP or a diet containing 0.2 % N-acetylcysteine (NAC) for 10 weeks, using aberrant crypt foci (ACF) as the endpoint. Additionally, two groups were fed with standard diet or a diet containing 5.0 % AP for 20 weeks, using colon tumors as the endpoint. In ACF assay, a reduction in the number of aberrant crypts (ACs) and ACF (1-3 AC) were observed in the groups fed with 5.0 % AP (37 % AC and 47 % ACF inhibition, p = 0.036) and 0.2 % NAC (39 % AC and 41 % ACF inhibition, p = 0.042). In tumor assay, a reduction in the number of invasive tumors (p < 0.005) and tumor multiplicity (p = 0.001) was observed in the group fed with 5.0 % AP. Also, a reduction in tumor Ki-67 cell proliferation (p = 0.003) and net growth index (p = 0.001) was observed in the group fed with 5.0 % AP. Therefore the findings of this study indicate that AP feeding may reduce the development of chemically-induced rat colon carcinogenesis.