The emerging role of signal transducer and activator of transcription 3 in cerebral ischemic and hemorrhagic stroke
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- 作者：Zhenxing Lianga ; b ; 1 ; zhenxingliang888@163.com" class="auth_mail" title="E-mail the corresponding author ; Guiling Wub ; 1 ; Chongxi Fanc ; 1 ; Jing Xua ; Shuai Jiangd ; Xiaolong Yanc ; Shouyin Dic ; Zhiqiang Mac ; Wei Hub ; Yang Yanga ; b ; yang200214yy@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：AD ; Alzheimer disease ; ADC ; apparent diffusion coefficient ; ADP ; adenosine diphosphate ; AGEs ; advanced glycation end products ; Akt ; protein kinase B ; AT1 ; angiotensin II type 1 receptors ; AT2 ; angiotensin II type 2 receptors ; A2aR ; adenosine A2a receptor ; ATF6 ; activating transcription factor 6 ; BBB ; blood brain barrier ; Bax ; Bcl-2 associated X ; Bcl-2 ; anti-apoptotic protein B cell lymphoma 2 ; CBV ; cerebral blood volume ; CLC ; cardiotrophin-like cytokine ; CNS ; central nervous system ; CNTF ; ciliar
- 刊名：Progress in Neurobiology
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：137
- 期：Complete
- 页码：1-16
- 全文大小：1225 K
文摘
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Introducing basic knowledge on STAT3 and briefly summarize the activation, inactivation, and regulation of STAT3 pathway.
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Describing the activation of STAT3 following cerebral ischemia and hemorrhage.
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Summarizing several significant cerebral ischemic and hemorrhagic stroke treatments that target the STAT3 signaling pathway, including drug and physical therapy.
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Discussing the physiopathological roles of STAT3 in cerebral ischemia and hemorrhage and highlighting research progress on STAT3 in stroke.
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This review presents a comprehensive picture of the role of STAT3 in the nervous system and may contribute to the promotion of STAT3 as a new therapeutic target.