Structural Basis for Substrate Selectivity of the E3 Ligase COP1
详细信息 查看全文
- 作者：Sacha Uljon1 ; 2 ; 3 ; Xiang Xu2 ; Izabela Durzynska1 ; 2 ; Sarah Stein4 ; Guillaume Adelmant1 ; 2 ; Jarrod A. Marto1 ; 2 ; Warren S. Pear4 ; Stephen C. Blacklow1 ; 2 ; 3 ; stephen_blacklow@hms.harvard.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Structure
- 出版年：2016
- 出版时间：3 May 2016
- 年：2016
- 卷：24
- 期：5
- 页码：687-696
- 全文大小：2853 K
文摘
- •
X-Ray structures reported for human and plant COP1 β-propeller-peptide complexes
- •
Trib1 peptides bind to a conserved surface on the top face of the propeller
- •
Structures reveal a universal mechanism for motif recognition by COP1
- •
Competition binding assays confirm importance of consensus VP sequence