Dephosphorylation Enables the Recruitment of 53BP1 to Double-Strand DNA Breaks
详细信息 查看全文
- 作者：Dong-Hyun Lee1 ; 6 ; Sanket S. Acharya1 ; 7 ; Mijung Kwon2 ; 3 ; 7 ; Pascal Drane1 ; Yinghua Guan4 ; Guillaume Adelmant5 ; Peter Kalev1 ; Jagesh Shah4 ; David Pellman2 ; 3 ; Jarrod A. Marto5 ; Dipanjan Chowdhury1 ; dipanjan_chowdhury@dfci.harvard.edu" class="auth_mail
- 刊名：Molecular Cell
- 出版年：8 May 2014
- 年：2014
- 卷：54
- 期：3
- 页码：512-525
- 全文大小：4378 K
文摘
- •
53BP1 is phosphorylated in mitosis to block recruitment to chromatin and DNA breaks
- •
Ectopic recruitment of 53BP1 to DNA lesions in mitosis promotes genomic instability
- •
PP4C/R3尾 phosphatase complex dephosphorylates 53BP1 during mitosis to G1 transition
- •
Dephosphorylation of 53BP1 is necessary for its function in the DNA damage response