• 作者：Julio Garcí ; a-Rodrí ; guez^a ; ^{jgarcia@hulp.insalud.es} ; Emilia Cantó ; n^b ; Javier Pemá ; n^c ; Maria Alvarez^d ; Guillermo Ezpeleta^e ; Amelia Gó ; mez-Nieto^f ; Isabel Iglesias^g ; Estrella Martí ; n-Mazuelos^h ; Inmaculada Ramí ; rez-de Ocarizⁱ ; Antonio Rezusta^j ; Gloria Royo-Garcí ; a^k ; Grupo de Estudio FUNGEMYCA &loz
• 关键词：Fungemia ; Candida ; Pediatrí ; a ; Epidemiologí ; a ; Neonatos ; Antifú ; ngicos
• 刊名：Enfermedades Infecciosas y Microbiolog¨ªa Cl¨ªnica
• 出版年：2013
• 出版时间：June-July, 2013
• 年：2013
• 卷：31
• 期：6
• 页码：363-368
• 全文大小：282 K

Introduction

There are few epidemiological studies on candidaemia in the paediatric population in Spain. We sought to determine the epidemiology of candidaemia in these patients.

Methods

Prospective, observational and multicentre study in 44 Spanish hospitals. All candidaemia episodes in paediatric patients from 0 to 15 years old between January 2009 and February 2010 were studied.

Results

There were 197 episodes and 200 species were isolated. The most frequent species was Candida parapsilosis sensu stricto (43 % ), followed by C. albicans (36 % ), C. tropicalis (6 % ), C. orthopsilosis, and C. glabrata (4 % ) respectively. C. albicans was the most prevalent in newborns, and C. parapsilosis was most frequent in the other age groups. As regards the regions of Spain, C. albicans was most prevalent in patients from Catalonia, the Balearic Islands and Canary Islands, and C. parapsilosis in patients from Andalusia, Castilla-Le¨®n, Galicia, Valencia, and Madrid. The rate of resistance to fluconazole was 1.5 % (4.1 % with the new species-specific Clinical and Laboratory Standards Institute [CLSI] criteria). Fluconazole resistance was lower in neonates than the other age groups. The Neonatal Wards were the areas with most episodes (31.5 % ). In the multivariate analysis, the variables associated independently with candidaemia due to C. albicans were: catheter (OR: 5.967; 95 % CI: 1.614-22.057; P = .007) and prematurity (OR: 2.229; 95 % CI: 1.141- 4.631; P = .020).

Conclusions

The epidemiology of paediatric candidaemia varies between Spanish regions, but, globally, C. parapsilosis and C. albicans, are respectively, the first and second most frequently isolated species, and they show resistance rates to fluconazole of less than 5 % .