A naproxen complex of dysprosium intercalates into calf thymus DNA base pairs

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• 作者：Mengsi Yang ; Jianhua Jin ; Guiqing Xu ; Fengling Cui ; Hongxia Luo
• 关键词：Dysprosium&ndash ; naproxen complex ; Intercalative binding ; ctDNA ; Interaction ; Fluorescence spectroscopy
• 刊名：Chemical Physics
• 出版年：15 January, 2014
• 年：2014
• 卷：428
• 期：Complete
• 页码：1-5
• 全文大小：977 K

文摘

The binding mode and mechanism of dysprosium-naproxen complex (Dy-NAP) with calf thymus deoxyribonucleic acid (ctDNA) were studied using UV-vis and fluorescence spectra in physiological buffer (pH 7.4). The results showed that more than one type of quenching process occurred and the binding mode between Dy-NAP with ctDNA might be intercalation. In addition, ionic strength, iodide quenching and fluorescence polarization experiments corroborated the intercalation binding mode between Dy-NAP and ctDNA. The calculated thermodynamic parameters 螖G, 螖H and 螖S at different temperature demonstrated that hydrophobic interaction force played a major role in the binding process.