A simple, efficient thermally promoted protocol for Huisgen-click reaction catalyzed by CuSO₄路5H₂O in water

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• 作者：Yuqin Jiang^a ; ^{jiangyuqin@htu.cn" class="auth_mail} ; Duanyang Kong^a ; Jinglin Zhao^a ; Weiwei Zhang^a ; Wenjing Xu^b ; Wei Li^a ; Guiqing Xu^a ; ^{guiqingxu@163.com" class="auth_mail}
• 关键词：Huisgen-click reaction ; Water ; Cycloaddition ; Triazoles ; Catalysts
• 刊名：Tetrahedron Letters
• 出版年：9 April, 2014
• 年：2014
• 卷：55
• 期：15
• 页码：2410-2414
• 全文大小：7877 K

文摘

A thermally promoted and CuSO₄-catalyzed new version of the Huisgen-click reaction is presented in this Letter. Notably, this protocol was suitable not only for the reactions between organic azides and alkynes, but also for one-pot three-component reactions among alkyl halides, NaN₃, and alkynes.