Elastomeric recombinant protein-based biomaterials
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- 作者：Nasim Annabi ; Suzanne M. Mithieux ; Gulden Camci-Unal ; Mehmet R. Dokmeci ; Anthony S. Weiss ; Ali Khademhosseini
- 关键词：Elastomer ; Tropoelastin ; Elastin-like polypeptides ; Biomaterials ; Elasticity
- 刊名：Biochemical Engineering Journal
- 出版年：2013
- 出版时间：15 August, 2013
- 年：2013
- 卷：77
- 期：Complete
- 页码：110-118
- 全文大小：2588 K
文摘
Elastomeric protein-based biomaterials, produced from elastin derivatives, are widely investigated as promising tissue engineering scaffolds due to their remarkable properties including substantial extensibility, long-term stability, self-assembly, high resilience upon stretching, low energy loss, and excellent biological activity. These elastomers are processed from different sources of soluble elastin such as animal-derived soluble elastin, recombinant human tropoelastin, and elastin-like polypeptides into various forms including three dimensional (3D) porous hydrogels, elastomeric films, and fibrous electrospun scaffolds. Elastin-based biomaterials have shown great potential for the engineering of elastic tissues such as skin, lung and vasculature. In this review, the synthesis and properties of various elastin-based elastomers with their applications in tissue engineering are described.