Is EBV Persistence In Vivo a Model for B Cell Homeostasis?

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• 作者：Gulfaraz Khan ; Emily M. Miyashita ; Bin Yang ; Gregory J. Babcock ; David A. Thorley-Lawson
• 刊名：Immunity
• 出版年：1996
• 出版时间：1 August 1996
• 年：1996
• 卷：5
• 期：2
• 页码：173-179
• 全文大小：790 K

文摘

We have measured the absolute numbers of EBV- infected B cells in the peripheral blood of healthy persistently infected individuals. Single measurements on a panel of 15 healthy individuals demonstrate that the frequency varies over a wide range from 1–50 per 10⁶ B cells. Repeat measurements over 1–3.5 years on several individuals whose frequencies varied over a 10-fold range showed that the variation does not represent the fluctuation in the frequency that can occur within an individual; rather, the frequencies are specific to the individual. The frequency within an individual measured over time is stable and contributes less than 10 % to the variance seen in the whole population. These measurements suggest that the level of EBV-infected B cells is tightly regulated and we propose that the same homeostatic mechanisms that regulate the levels of normal B cells also regulate B cells latently infected with EBV.