Bone remodeling during pregnancy and post-partum assessed by metal lead levels and isotopic concentrations
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- 作者：Brian Gulsona ; b ; brian.gulson@mq.edu.au" class="auth_mail" title="E-mail the corresponding author ; Alan Taylorc ; alan.taylor@mq.edu.au" class="auth_mail" title="E-mail the corresponding author ; John Eismand ; e ; j.eisman@garvan.org.au" class="auth_mail" title="E-mail the corresponding author
- 关键词：Bone ; Remodeling ; Markers ; Lead ; Lead isotopic ; Fetal exposure ; Epigenetics
- 刊名：Bone
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：89
- 期：Complete
- 页码：40-51
- 全文大小：883 K
文摘
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There are conflicting data on bone remodeling during pregnancy and post-partum
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We describe an alternative highly sensitive approach using levels of the metal lead and its isotopic composition
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Studies demonstrate bone resorption with increased lead release from the maternal skeleton in later pregnancy and lactation
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The data for the Australian subjects are consistent with multi-generational passage of lead.