Cotranslational Protein Folding inside the Ribosome Exit Tunnel
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- 作者：Ola B. Nilsson1 ; 8 ; Rickard Hedman1 ; 8 ; Jacopo Marino2 ; Stephan Wickles2 ; Lukas Bischoff2 ; Magnus Johansson3 ; Annika Mü ; ller-Lucks1 ; Fabio Trovato6 ; Joseph D. Puglisi4 ; 5 ; Edward P. O&rsquo ; Brien6 ; Roland Beckmann2 ; Gunnar von Heijne1 ; 7 ; gunnar@dbb.su.se" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2015
- 出版时间：8 September 2015
- 年：2015
- 卷：12
- 期：10
- 页码：1533-1540
- 全文大小：2109 K
文摘
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Cotranslational folding is studied by arrest-peptide-mediated force measurements
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Single-molecule measurements show that a pulling force prevents ribosome stalling
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A ribosome-tethered zinc-finger domain is visualized by cryo-EM (electron microscopy)
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The zinc-finger domain is shown to fold deep inside the ribosome exit tunnel