Selective dentate gyrus disruption causes memory impairment at the early stage of experimental multiple sclerosis

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• 作者：Vincent Planche^a ; ^b ; ^c ; ^{planche.vincent@gmail.com} ; Aude Panatier^a ; ^b ; Bassem Hiba^b ; ^d ; Eva-Gunnel Ducourneau^a ; ^b ; Gerard Raffard^b ; ^e ; Nadè ; ge Dubourdieu^a ; ^b ; Marlè ; ne Maitre^a ; ^b ; Thierry Lesté ; -Lasserre^a ; ^b ; Bruno Brochet^a ; ^b ; ^f ; Vincent Dousset^a ; ^b ; ^f ; Aline Desmedt^a ; ^b ; Sté ; phane H. Oliet^a ; ^b ; Thomas Tourdias^a ; ^b ; ^f
• 关键词：Multiple sclerosis ; Experimental autoimmune encephalomyelitis ; Hippocampus ; Dentate gyrus ; Memory impairment ; Synaptic plasticity ; Microglia ; Diffusion tensor imaging
• 刊名：Brain, Behavior, and Immunity
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：60
• 期：Complete
• 页码：240-254
• 全文大小：3994 K
• 卷排序：60

文摘

Dentate gyrus is selectively vulnerable to microglial activation at the early stage of experimental multiple sclerosis. Dentate gyrus disruption causes memory impairment at the early stage of experimental multiple sclerosis. Intra-dentate gyrus or systemic injections of minocycline prevent memory impairment in experimental multiple sclerosis. High-resolution diffusion tensor imaging can capture in vivo the selective alteration of the dentate gyrus.