Aberrant proplatelet formation in chronic myeloproliferative neoplasms

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• 作者：Michaela Muth ; Guntram B&#xfc ; sche ; Oliver Bock ; Kais Hussein ; Hans Kreipe
• 关键词：Proplatelets ; Primary myelofibrosis ; Pseudopodia ; Megakaryocytes ; Fibrosing and non-fibrosing MPN
• 刊名：Leukemia Research
• 出版年：2010
• 出版时间：November 2010
• 年：2010
• 卷：34
• 期：11
• 页码：1424-1429
• 全文大小：980 K

文摘

Proplatelets represent pseudopodia of megakaryocytes which extend into bone marrow sinuses to release platelets. Proplatelets were visualized by immunohistochemical and confocal microscopy. In trephines from essential thrombocythaemia (ET, n = 10), fibrotic (n = 10) and pre-fibrotic (n = 10) primary myelofibrosis (PMF) there was a significant increase of proplatelet density compared with normal bone marrow samples (n = 10; p < 0.001). Manifest fibrosis exhibited the highest density and volume ratio with significant differences to non-fibrotic PMF (p < 0.001) and ET (p < 0.001). This study demonstrates that besides megakaryocytic proliferation extensive pseudopodial proplatelet formation provides a hallmark of MPN. Fibrosing differ from non-fibrosing MPN by density and size of aberrant proplatelets.