Allelic diversity of KIR3DL1/3DS1 in a southern Chinese population

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• 作者：Zhihui Deng^a ; ^{zhihui_deng@aliyun.com" class="auth_mail" title="E-mail the corresponding author} ; Jianxin Zhen^a ; ^{jianxinzhen1988@qq.com" class="auth_mail" title="E-mail the corresponding author} ; Bofeng Zhu^b ; ^{zhubofeng7372@126.com" class="auth_mail" title="E-mail the corresponding author} ; Guobing Zhang^a ; ^{hypuris@163.com" class="auth_mail" title="E-mail the corresponding author} ; Qiong Yu^a ; ^{Yuqiong7867@aliyun.com" class="auth_mail" title="E-mail the corresponding author} ; Daming Wang^a ; ^{riverch888@aliyun.com" class="auth_mail" title="E-mail the corresponding author} ; Yunping Xu^a ; ^{yunpingxu1982@aliyun.com" class="auth_mail" title="E-mail the corresponding author} ; Liumei He^a ; ^{littleduckmei@163.com" class="auth_mail" title="E-mail the corresponding author} ; Liang Lu^a ; ^{luliang@126.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：KIR ; killer cell immunoglobulin-like receptor ; HLA ; human leukocyte antigens ; LRC ; leukocyte receptor complex ; NK cells ; natural killer cells ; AIDS ; acquired immuno deficiency syndrome ; HIV ; human immunodeficiency virus ; HCV ; hepatitis C virus ; cDNA ; complementary DNA ; SBT ; sequencing-based typing ; SSP ; sequence specific primer ; HSCT ; hematopoietic stem cell transplantation
• 刊名：Human Immunology
• 出版年：2015
• 出版时间：September 2015
• 年：2015
• 卷：76
• 期：9
• 页码：663-666
• 全文大小：345 K

文摘

The inhibitory KIR3DL1 and the activating KIR3DS1 segregate as alleles of the same locus. KIR3DL1 is highly diversified at the allele level and KIR3DL1 alleles exhibit varied levels of expression and ligand binding affinity resulting in varied degrees of NK cell inhibition. Previous studies have shown that the KIR3DL1/3DS1 polymorphism associated with viral infection, cancer and transplantation. However, little is known about the population distribution of KIR3DL1/3DS1 alleles in Chinese. The present study examined allelic diversity of KIR3DL1/3DS1 in a southern Chinese population (N = 306) using PCR-SSP and sequencing based typing. The presence of KIR3DL1 and KIR3DS1 were detected in 97.1% and 34.0% of the tested individuals respectively. A total of 10 KIR3DL1 alleles (including 2 novel ones) and 6 KIR3DS1 alleles (including 5 novel ones) were identified. Common KIR3DL1 alleles (>10%) were KIR3DL1*01502 (74.8%), KIR3DL1*00501 (23.9%) and KIR3DL1*00701 (15.7%). KIR3DS1*01301 was the predominant KIR3DS1 allele with other KIR3DS1 alleles only sporadically observed. The knowledge of the allelic polymorphism of KIR3DL1/3DS1 may help to better understand the role played by KIR3DL1/3DS1 in associated diseases and clinical transplantation in southern Chinese.