TCDD promoted EMT of hFPECs via AhR, which involved the activation of EGFR/ERK signaling
详细信息 查看全文
- 作者：Zhan Gaoa ; b ; 1 ; Yongjun Bua ; 1 ; Xiaozhuan Liuc ; 1 ; Xugang Wanga ; Guofu Zhanga ; Erhui Wanga ; Shibin Dinga ; Yongfeng Liua ; Ruling Shia ; Qiaoyun Lib ; Jianhong Fub ; Zengli Yua ; d ; zly@zzu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：2 ; 3 ; 7 ; 8-Tetrachlorodibenzo-p-dioxin (TCDD) ; Epithelial-mesenchymal transition (EMT) ; Human fetal palatal epithelial cells (hFPECs) ; EGFR/ERK pathway ; Cleft palate
- 刊名：Toxicology and Applied Pharmacology
- 出版年：2016
- 出版时间：1 May 2016
- 年：2016
- 卷：298
- 期：Complete
- 页码：48-55
- 全文大小：959 K
文摘
- •
TCDD exposure promoted cell proliferation and EMT of hFPECs;
- •
AhR signaling was activated and required for TCDD-induced EMT;
- •
TCDD-mediated EMT of hFPECs involved the activation of EGFR/ERK signaling;
- •
TCDD exposure had no effect on TGFβ3/Smad pathway.