Oral delivery of insulin using CaCO₃-based composite nanocarriers with hyaluronic acid coatings

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• 作者：Depeng Liu^a ; Guohua Jiang^a ; ^b ; ^c ; ^{ghjiang_cn@zstu.edu.cn} ; Weijiang Yu^a ; Lei Li^a ; Zaizai Tong^a ; ^b ; ^c ; Xiangdong Kong^d ; Juming Yao^a ; ^b ; ^c
• 关键词：Inorganic nanocarriers ; Hyypoglycemic effect ; Insulin ; Oral delivery
• 刊名：Materials Letters
• 出版年：2017
• 出版时间：1 February 2017
• 年：2017
• 卷：188
• 期：Complete
• 页码：263-266
• 全文大小：562 K
• 卷排序：188

文摘

A facile and green emulsion co-precipitation method has been developed for CaCO3/HA-nanocarriers. CaCO3/HA-nanocarriers can be used to delivery of insulin by oral administration. An effective hypoglycemic effect is obtained in comparison with subcutaneous injection of insulin.