Fabrication of biodegradable composite microneedles based on calcium sulfate and gelatin for transdermal delivery of insulin

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• 作者：Weijiang Yu^a ; Guohua Jiang^a ; ^b ; ^c ; ^{ghjiang_cn@zstu.edu.cn} ; Depeng Liu^a ; Lei Li^a ; Hua Chen^a ; Yongkun Liu^a ; Qin Huang^a ; Zaizai Tong^a ; ^b ; ^c ; Juming Yao^a ; ^b ; ^c ; Xiangdong Kong^d
• 关键词：Biodegradable ; Microneedles ; Insulin ; Transdermal delivery ; Hypoglycemic effect
• 刊名：Materials Science and Engineering: C
• 出版年：2017
• 出版时间：1 February 2017
• 年：2017
• 卷：71
• 期：Complete
• 页码：725-734
• 全文大小：2144 K
• 卷排序：71

文摘

The biodegradable composite microneedles based on calcium sulfate and gelatin have been prepared. The resultant microneedles can be used to delivery of insulin by transdermal administration. An effective hypoglycemic effect is obtained in comparison with subcutaneous injection of insulin.