Safety and efficacy of autologous thymosin β4 pre-treated endothelial progenitor cell transplantation in patients with acute ST segment elevation myocardial infarction: A pilot study

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• 作者：Junhui Zhu ; Jiale Song ; Lu Yu ; Hao Zheng ; Binquan Zhou ; Shaoxiang Weng ; Guosheng Fu ; ^{zhujhzju@163.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：acute myocardial infarction ; endothelial progenitor cell ; thymosin β4 ; transplantation
• 刊名：Cytotherapy
• 出版年：2016
• 出版时间：August 2016
• 年：2016
• 卷：18
• 期：8
• 页码：1037-1042
• 全文大小：227 K

文摘

Experimental studies and clinical trials suggest that endothelial progenitor cell (EPC) transplantation can repair “broken” heart. However, transplantation of autologous EPCs has numerous limitations, including the limited supply of expanded EPCs, the impaired function and activity of the transplanted cells and so on. Therefore, we investigated the feasibility, safety and initial clinical outcome of autologous thymosin β4 (Tβ4) pre-treated EPC transplantation in patients with acute ST segment elevation myocardial infarction (STEMI).

Methods

Ten patients with STEMI were included; they were randomized to 2 groups: EPC transplantation group (control group; n = 5) and Tβ4-pre-treated EPC transplantation group (experimental group; n = 5). EPCs were pre-treated with Tβ4 24 hours before transplantation in experimental group. Cardiac function was evaluated using echocardiography and emission computed tomography, as well as the 6-min walking test before and 6 months after the intervention.

Results

After 6 months of follow-up, the average 6-min walking distance was increased by 38.2 m (from 263 ± 42 m to 302 ± 34 m) in the control group and 75.7 m (from 264 ± 42 m to 340 ± 44 m) in the experimental group; the average difference of the 6-min walking distance was 37.5 m (95% confidence interval [CI], 28.7–56.3 m; P < 0.01). In addition, the cardiac function in the experimental group was more significantly improved than that of the control group. There were no severe complications related to the procedure in either group during the follow-up.

Discussion

Our pilot study suggested that Tβ4-optimized EPC transplantation appeared to be feasible and safe, and might have beneficial effects on exercise capacity and left ventricular function in patients with STEMI.