Leptin enhances the invasive ability of glioma stem-like cells depending on leptin receptor expression

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• 作者：Guosheng Han ; Wenyuan Zhao ; Laixing Wang ; Zhijian Yue ; Rui Zhao ; Yanan Li ; Xiaoping Zhou ; Xiaowu Hu ; Jianmin Liu
• 关键词：Glioma stem-like cells ; Leptin ; Leptin receptor ; Invasion
• 刊名：Brain Research
• 出版年：16 January, 2014
• 年：2014
• 卷：1543
• 期：Complete
• 页码：1-8
• 全文大小：5440 K

文摘

Glioma stem-like cells have been demonstrated to have highly invasive activity, which is the major cause of glioma recurrence after therapy. Leptin plays a role in glioma invasion, however, whether and how leptin contributes to the biological properties of glioma stem-like cells, such as invasion, remains to be explored. In the current study, we aimed to explore the role of leptin during glioma stem-like cells invasion as well as the signaling pathway. We found that glioma stem-like cells exhibited high invasive potential, especially in the presence of leptin, Ob-R coexpressed with CD133 in glioma stem-like cells was showed to be responsible for leptin mediated invasion of glioma stem-like cells. Our results indicated that leptin served as a key intermediary linking the accumulation of excess adipokine to the invasion of glioma stem-like cells, which may be a novel therapeutic target for suppressing tumor invasion and recurrence.