Glial cell line-derived neurotrophic factor protects midbrain dopaminergic neurons against lipopolysaccharide neurotoxicity
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- 作者：Bin Xing ; Tao Xin ; Lingling Zhao ; R ; y L. Hunter ; Yan Chen ; Guoying Bing
- 关键词：Parkinson's disease ; GDNF ; Dopaminergic neurons ; Microglia ; Nitric oxide ; PI3K
- 刊名：Journal of Neuroimmunology
- 出版年：2010
- 出版时间：25 August 2010
- 年：2010
- 卷：225
- 期：1-2
- 页码：43-51
- 全文大小：1168 K
文摘
Aberrant microglia activation causes dopaminergic neuronal loss and nitric oxide produced by microglia plays a critical role in dopaminergic neuronal degeneration. However, no study has determined if GDNF protects dopaminergic neurons via inhibiting nitric oxide generation in Parkinson's disease animal model. We report that GDNF not only reduces lipopolysaccharide-induced degeneration of dopaminergic neurons, suppresses microglia activation and nitric oxide generation, but also reverses the inhibition of phosphoinositide 3-kinase (PI3K) in dopaminergic neurons and microglia. It suggests that the neuroprotective effect of GDNF on dopaminergic neurons may be related to its suppression of microglia activation-mediated nitric oxide via releasing the inhibition of PI3K in both neurons and microglia.