Engineering physical microenvironment for stem cell based regenerative medicine

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• 作者：Yu Long Han¹ ; ² ; ⁶ ; Shuqi Wang³ ; ⁶ ; Xiaohui Zhang¹ ; ² ; Yuhui Li¹ ; ² ; Guoyou Huang¹ ; ² ; Hao Qi² ; Belinda Pingguan-Murphy⁴ ; Yinghui Li⁵ ; Tian Jian Lu² ; ^{tjlu@mail.xjtu.edu.cn" class="auth_mail} ; Feng Xu¹ ; ² ; ^{fengxu@mail.xjtu.edu.cn" class="auth_mail}
• 刊名：Drug Discovery Today
• 出版年：June 2014
• 年：2014
• 卷：19
• 期：6
• 页码：763-773
• 全文大小：2019 K

文摘

Regenerative medicine has rapidly evolved over the past decade owing to its potential applications to improve human health. Targeted differentiations of stem cells promise to regenerate a variety of tissues and/or organs despite significant challenges. Recent studies have demonstrated the vital role of the physical microenvironment in regulating stem cell fate and improving differentiation efficiency. In this review, we summarize the main physical cues that are crucial for controlling stem cell differentiation. Recent advances in the technologies for the construction of physical microenvironment and their implications in controlling stem cell fate are also highlighted.