“Endocytic pH regulates cell surface localization of glycolipid antigen loaded CD1d complexes”
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- 作者：Pooja Aroraa ; 1 ; Shalu S. Kharkwala ; 1 ; Tony W. Nga ; Shajo Kunnath-Velayudhana ; Neeraj K. Sainia ; Christopher T. Johndrowa ; Young-tae Changc ; Gurdyal S. Besrad ; Steven A. Porcellia ; b ; steven.porcelli@einstein.yu.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：CD1d ; αGC ; NKT cells ; Glycolipid ; Antigen presentation ; NK activation ; transactivation ; IFNγ secretion ; Dendritic cells ; Endosomal presentation ; Endosomal pH ; pH neutralization
- 刊名：Chemistry and Physics of Lipids
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：194
- 期：Complete
- 页码：49-57
- 全文大小：1432 K
文摘
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Neutralization of endosomal pH increases presentation of Th2-biasing αGC analogues, and their association with CD1d in cholesterol rich “lipid raft” microdomains.
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Pulsing the antigen presenting cells with αGC Th2-agonist in the presence of chloroquine induces higher NK cell transactivation.