Anti-inflammatory effects and antioxidant activity of dihydroasparagusic acid in lipopolysaccharide-activated microglial cells
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- 作者：Adele Salemmea ; adele.salemme@uniroma1.it" class="auth_mail" title="E-mail the corresponding author ; Anna Rita Tognaa ; Arianna Mastrofrancescoc ; Vittoria Cammisottoa ; Monica Ottavianic ; Armandodoriano Biancob ; Alessandro Vendittib ; d
- 关键词：AA ; arachidonic acid ; COX-2 ; cyclooxygenase-2 ; DHAA ; dihydroasparagusic acid ; iNOS ; inducible nitric oxide synthase ; LOX ; lipoxygenase ; LPS ; lipopolysaccharide ; MAPK ; mitogen activated protein kinase ; NF-κB ; nuclear factor-kB ; NO ; nitric oxide ; PGE2 ; prostaglandin E2 ; ROS ; reactive oxygen species ; TNF-α ; tumor necrosis factor-α
- 刊名：Brain Research Bulletin
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：120
- 期：Complete
- 页码：151-158
- 全文大小：1489 K
文摘
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ar0005">Dihydroasparagusic acid reduces inflammatory and oxidative processes.
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ar0010">DHAA prevents rat microglial activation.
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ar0015">Dihydroasparagusic acid prevents lipopolysaccharide-induced production of pro-inflammatory mediators.