The Use of MgO-paste as a Biodegradeable Bone Cement

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• 作者：Anders Biel^a ; Mobina Chaudhry^b ; Stefan Gustafsson^c ; Hå ; kan Nygren^b ; ^{hakan.nygren@gu.se" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Bone formation ; bone cement ; Magnesium ; bone healing ; osteoporosis
• 刊名：Materials Today: Proceedings
• 出版年：2016
• 出版时间：2016
• 年：2016
• 卷：3
• 期：2
• 页码：556-561
• 全文大小：522 K

文摘

The use of MgO-paste as bone cement was tested on titanium cylinders implanted into rat tibia. The evaluation of bone healing was made with the retention force (pull-out) test, light microscopy and ESEM/ EDX. Preimplantation of the MgO-paste into drill perforations of rat tibia increased the retention of the titanium implant 6-fold. The error was expressed as the 95% confidence interval of means (n=10 bones in each group). The observed difference between 3.46+/-0.71 N/mm² for Ti-cylinders implanted with MgO-paste and 0.56+/-0.26 N/mm² for Ti-cylinders implanted directly into the bone, is statistically significant (p<0.01). The increase of retention force, caused by MgO is parallel to an increased thickness of the compact bone surrounding the implant and closer contact between bone and implant.

Histological examination of the implant-related bone showed that the MgO-induced bone growth is mediated by the formation of a bone-inducing matrix. The matrix contains organic substance, most likely proteins.