Retrospective cohort.
One hundred twenty-five patients from the New York Glaucoma Progression Study with both ¦Â-zone PPA and VF progression.
Treated open-angle glaucoma patients with 8 or more Swedish Interactive Threshold Algorithm Standard 24-2 VFs (Humphrey Field Analyzer II; Carl Zeiss Meditec, Inc., Dublin, CA) in either eye were identified. Eyes with optic disc photographs, ¦Â-zone PPA, less than 6 diopters myopia, and VF progression were studied. Visual field progression was defined using trend analysis as the presence of at least 2 adjacent progressing points in the same hemifield using standard pointwise linear regression (PLR) criteria.
The correlation between ¦Â-zone PPA and location of most rapid future VF progression.
One hundred twenty-five eyes (125 patients; mean age, 71.9¡À12.3 years; 58 % women; 75 % European descent) with ¦Â-zone PPA and VF progression were enrolled. The mean follow-up was 6.8¡À1.7 years and the mean number of VFs was 12.5¡À3.6. Ninety-three patients (74 % ) had more ¦Â-zone PPA inferiorly and 32 patients (26 % ) had more ¦Â-zone PPA superiorly. The fastest VF progression occurred in the superior hemifield in 77 patients (62 % ) and in the inferior hemifield in 48 (38 % ) patients. Patients with superior VF progression had a superior localized mean rate of progression of ?.57¡À1.7 dB/year, and patients with inferior VF progression had an inferior localized mean rate of ?.94¡À1.4 dB/year (P = 0.012). The mean number of points reaching the predefined PLR end points was 5.6¡À7.5 for the superior VF hemifield and 3.0¡À4.9 for the inferior hemifield (P = 0.006). The hemifield with more points reaching PLR progression end points, with fastest average velocity of progression, or both was spatially consistent with the location of largest ¦Â-zone PPA in 89 (71 % ) patients (P = 0.0001, Fisher exact test; ¦Ê = 0.35; 95 % confidence interval, 0.17?.53).
In treated glaucoma patients with ¦Â-zone PPA and VF progression, the location of largest ¦Â-zone PPA typically correlates spatially with the region of the most rapid future VF progression.
The author(s) have no proprietary or commercial interest in any materials discussed in this article.