• 作者：Pablo Guillermo Gó ; mez^a ; Daniel Gustavo Politis^b ; ^{dpolitis@psi.uba.ar} ; Wanda Yanina Rubinstein^c
• 关键词：Apraxia ; Demencia frontotemporal variante ; frontal ; Demencia tipo Alzheimer ; Imitació ; n
• 刊名：Neurolog¨ªa Argentina
• 出版年：2010
• 出版时间：April-June 2010
• 年：2010
• 卷：2
• 期：2
• 页码：90-95
• 全文大小：414 K

Introduction

Apraxia in Alzheimer's dementia patients is commonly explored and reported (Rapcsak et al, 1989; Ochipa et al, 1992), while the presence of apraxia has not been systematically studied in frontal variant of frontotemporal dementia.

Objective

The objectives of this work are search for evidence of apraxia in frontal variant of frontotemporal dementia, and identify if there are different praxis performance patterns in Alzheimer's dementia and frontal variant of frontotemporal dementia patients.

Patients and methods

50 patients diagnosed with Alzheimer's dementia and 40 patients diagnosed with frontal variant of frontotemporal dementia, evaluated with the cognitive praxis assessment battery (Politis, 2003).

Results

90 % of both groups of patients showed alterations in at least one test of praxis battery. The Mann-Whitney test, confirm the existence of statistically significant differences in performance on imitation of unfamiliar gestures, with the worst performance on Alzheimer's dementia group.

Conclusions

These findings are consistent with the report of a marked deficit in the imitation of unfamiliar gestures in Alzheimer's dementia (Ska et al, 1990; Mozaz et al, 1999). The coding of motion underlying to the repetition of an action, primarily activated parietal areas. The differences in performance on the imitation of unfamiliar gestures could be explained from a differential in parietal area's deficit.