• 作者：Pablo Guillermo Gó ; mez^a ; ^b ; Daniel Gustavo Politis^a ; ^c ; ^{dpolitis@psi.uba.ar}
• 关键词：Apraxia ; Demencia frontotemporal variante frontal ; Deterioro cognitivo ; Marcador cognitivo
• 刊名：Neurolog¨ªa Argentina
• 出版年：2011
• 出版时间：October-December 2011
• 年：2011
• 卷：3
• 期：4
• 页码：203-209
• 全文大小：252 K

Introduction

The descriptions of apraxia in frontal variant of frontotemporal dementia (fvFTD) are often isolated and contradictory (Blass & Rabins, 2009; Donoso & Salinas, 2009). Have not yet been reported correlations between apraxia and severity of dementia in fvFTD.

Objective

To study the relationship between the severity of dementia and the apraxia in patients with fvFTD. Compare praxis tests with social cognition and executive functions tasks in their ability to function as indicator of the severity of dementia in patients with fvFTD.

Patients and methods

Have been evaluated 24 patients with vfFTD (Lund & Manchester, 1994; Neary et al., 1998). We used the Cognitive Battery Assessment of Apraxias (Politis, 2003) to assess the praxis performance, and the Mini-Mental State Examination (Folstein et al., 1975), Test Clock (Freedman et al., 1994) and Clinical Dementia Rating (CDR) (Hughes et al., 1982) to quantify the degree of cognitive impairment for each patient. It was used social cognition and executive function tasks to assess these domains.

Results

Performance on praxis battery correlated with measures of severity of dementia. In turn, patients with greater cognitive impairment have performed significantly worse in the praxis battery.

Conclusions

These results suggest a relationship between apraxia and severity of dementia in vfFTD, not previously described in the literature. Also, the apraxia is presented as an early cognitive marker of vfFTD, reinforcing the finding of systematical praxic alterations on this type of dementia (Rubinstein and Politis, 2007).