Synthesis and pharmacological evaluation of a new class of peroxisome proliferator-activated receptor modulators
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文摘
A series of 5-substituted 2-benzoylaminobenzoic acids has been synthesized and assayed for PPARα/γ activity. Both dual activators and selective PPARγ agonists have been identified. This class of compounds was shown to activate the PPARγ receptor through interaction with a novel binding site.