Evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase

详细信息    查看全文

• 作者：Shankaran ; K. ; Donnelly ; Karla L. ; Shah ; Shrenik K. ; Guthikonda ; Ravindra N. ; MacCoss ; Malcolm ; et. al.
• 关键词：NOS ; Pyrrolidin-2-imine ; 1 ; 3-Thiazolidin-2-imine
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2004
• 出版时间：September 6, 2004
• 年：2004
• 卷：14
• 期：17
• 页码：4539-4544
• 全文大小：272 K

文摘

Syntheses and evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase (NOS) are discussed. An extensive SAR was established for pyrrolidin-2-imines class of compounds. The amidines came out as the most potent inhibitors in addition to displaying selectivity.