Enriched environment decreases microglia and brain macrophages inflammatory phenotypes through adiponectin-dependent mechanisms: Relevance to depressive-like behavior
详细信息 查看全文
- 作者：Joë ; lle Chabry ; Sarah Nicolas ; Julie Cazareth ; Emilie Murris ; Alice Guyon ; Nicolas Glaichenhaus ; Catherine Heurteaux ; Agnè ; s Petit-Paitel ; paitel@ipmc.cnrs.fr" class="auth_mail" title="E-mail the corresponding author
- 关键词：ApN ; adiponectin ; EE ; enriched environment ; SE ; standard environment ; LPS ; lipopolysaccharide ; CNS ; central nervous system ; CBA ; cytometric bead array&trade ; IL ; interleukin ; TLR4 ; toll like receptor-4 ; CCR2 ; C-C chemokine receptor type 2 ; CCL2 ; chemokine ligand 2 ; MHC class II ; major histocompatibility complex class II ; TNF ; tumor necrosis factor ; CSF ; cerebrospinal fluid ; HPA ; hypothalamic&ndash ; pituitary&ndash ; adrenal ; i.c.v. ; intracerebroventricular ; FSC ; forward scatter ; SSC ; side scatter
- 刊名：Brain, Behavior, and Immunity
- 出版年：2015
- 出版时间：November 2015
- 年：2015
- 卷：50
- 期：Complete
- 页码：275-287
- 全文大小：2110 K
文摘
- •
Depression induced by chronic corticosterone treatment generates neuroinflammation.
- •
Enriched environment reduces depression-linked neuroinflammation.
- •
Enriched environment promotes anti-inflammatory microglia and brain macrophage phenotype.
- •
Adiponectin exerts anti-inflammatory properties by acting on microglia and brain macrophages.
- •
Adiponectin intracerebroventricular injection reduces depressive-like behavior.