Bis(pyrazolyl) palladium(II), platinum(II) and gold(III) complexes: Syntheses, molecular structures and substitution reactions with l

详细信息    查看全文

• 作者：Frankline K. Keter ; Stephen O. Ojwach ; Olayinka A. Oyetunji ; Ilia A. Guzei ; James Darkwa
• 关键词：Bis(pyrazolyl)acetic acid compounds ; Cytotoxicity ; Pseudo first-order ; Substitution ; l-cysteine
• 刊名：Inorganica Chimica Acta
• 出版年：2009
• 出版时间：1 June 2009
• 年：2009
• 卷：362
• 期：8
• 页码：2595-2602
• 全文大小：497 K

文摘

A series of pyrazolyl palladium(II), platinum(II) and gold(III) complexes, [PdCl₂(3,5-R₂bpza)] {R = H (1), R = Me (2), bpza = bis-pyrazolyl acetic acid}, [PtCl₂(3,5-R₂bpza)] {R = H (3a), R = Me (4)}, [AuCl₂(3,5-R₂bpza)]Cl {R = H (5a), R = Me (6a)} and [PdCl₂(3,5-R₂bpzate)] {R = Me (7)} have been synthesised and structurally characterised. Single crystal X-ray crystallography showed that the pyrazolyl ligands exhibit N^N-coordination with the metals. Anticancer activities of six complexes 1–6a were investigated against CHO cells and were found to have low activities. Substitution reactions of selected complexes 1, 2, 3a and 5a with l-cysteine show that the low anticancer activities compounds and that the rate of substitution with sulfur-containing compounds is not the cause of the low anticancer activities.