Platinum(II) and gold(I) complexes based on 1,1¡ä-bis(diphenylphosphino)metallocene derivatives: Synthesis, characterization and biological activity of?the?gold complexes

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• 作者：Haris Bjelosevic ; Ilia A. Guzei ; Lara C. Spencer ; Tina Persson ; Frederik H. Kriel ; Raymond Hewer ; Margo J. Nell ; Jiri Gut ; Constance E.J. van Rensburg ; Philip J. Rosenthal ; Judy Coates ; James Darkwa ; Sofi K.C. Elmroth
• 关键词：Bis(diphenylphosphino)ferrocenyl- ; Bis(diphenylphosphino)ruthenocenyl- ; Platinum and gold complexes ; Anticancer ; AntiHIV ; Antimalarial agents
• 刊名：Journal of Organometallic Chemistry
• 出版年：2012
• 出版时间：1 December, 2012
• 年：2012
• 卷：720
• 期：Complete
• 页码：52-59
• 全文大小：1109 K

文摘

The synthesis of series of 1,2,1¡ä substituted bis(diphenylphosphino)- ruthenocenyl (1-4) and ferrocenyl cis-platinum(II) (5-7) and gold(I) (8-12) complexes are described. Crystal structures of 2 and 4, as well as 5, 6 and 10 confirm the molecular geometry of these ligands and their metal complexes. Preliminary investigation of four gold complexes as potential anticancer, antiHIV and antimalaria showed at least one gold compound that has excellent activity towards one of these diseases. The three gold(I) complexes, {1- [1-(dimethylamino)ethyl]-1 ,2-bis(diphenylphosphino)ruthenocene-¦Ê²P,P¡ä}bis[chlorogold(I)] (8) (IC₅₀?=?1.40?¦ÌM), {1-[1-(acetoxyethyl)-1¡ä,2-bis(diphenylphosphino)ferrocene-¦Ê²P,P¡ä]bis[chlorogold(I)] (9) (IC₅₀?=?0.51?¦ÌM), {1-[1-(3-carboxypropanamido)ethyl]-1¡ä,2-bis(diphenylphosphino)-ruthenocene¦Ê²P,P¡ä}bis[chlorogold(I)] (12) (IC₅₀?=?1.784?¦ÌM), have the best activities against cancer, HIV and malaria respectively.