- 作者：Young Ho Lee ; lyhcgh@korea.ac.kr" class="auth_mail ; Jae-Hoon Kim ; Young Ho Seo ; Sung Jae Choi ; Jong Dae Ji ; Gwan Gyu Song
- 刊名：Human Immunology
- 出版年：May, 2014
- 年：2014
- 卷：75
- 期：5
- 页码：414-421
- 全文大小：1110 K
Objective
The aim of this study was to explore whether the cytotoxic T lymphocyte associated antigen-4 (CTLA-4) polymorphisms are associated with susceptibility to ulcerative colitis (UC) and Crohn鈥檚 disease (CD).Methods
The authors conducted a meta-analysis on associations between CTLA-4 +49 A/G, 鈭?18 C/T, CT60 A/G polymorphisms, and (AT)n repeat in the 3鈥?untranslated region (UTR) and UC and CD susceptibility.
Results
A total of 15 comparison studies were considered in our meta-analysis. Meta-analysis revealed no association between UC and the CTLA-4 +49 G and CTLA-4 鈭?18 T alleles in all subjects (OR = 0.982, 95% CI = 0.851-1.1339, p = 0.804; OR = 0.500, 95% CI = 0.223-1.124, p = 0.094). No association was found between UC and the CTLA-4 CT60 A/G polymorphism in Europeans. However, a significant association was observed between the longer allele (猢?18 bp) of the (AT)n and UC in Asian population (OR = 6.073, 95% CI = 4.246-8.684, p = 1.0 脳 10鈭?). Meta-analysis of the CTLA-4 +49 A/G, 鈭?18 C/T, CT60 A/G polymorphisms showed no association with CD.
Conclusions
This meta-analysis demonstrates that the CTLA-4 (AT)n repeat in 3鈥?UTR may be associated with susceptibility to UC in Asians, while no association was found between the CTLA-4 +49 A/G, 鈭?18 C/T, and CD60 A/G polymorphism and susceptibility to UC and CD.