Endophenotype best practices

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• 作者：William G. Iacono^a ; ^{wiacono@umn.edu} ; Stephen M. Malone^a ; Scott I. Vrieze^b
• 关键词：Endophenotype ; Biomarker ; Heritability ; Genes ; GWAS ; GREML ; Candidate gene ; Data sharing
• 刊名：International Journal of Psychophysiology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：111
• 期：Complete
• 页码：115-144
• 全文大小：1929 K
• 卷排序：111

文摘

The potential of endophenotypes for identifying psychopathology-related genes has been oversold. Endophenotypes have largely failed to produce verified molecular genetic associations. Endophenotypes are complex and influenced by many genes each with very small effect. Extremely large samples are necessary to discover variants associated with endophenotypes. Endophenotype research should be informed by molecular genetic findings. Endophenotypes are valuable even without producing molecular genetic hits.