Differences in Some Behavioural Effects of Deprenyl and Amphetamine Enantiomers in Rats

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• 作者：Timá ; r ; Julia ; Gyarmati ; Zsuzsanna ; Barna ; Lá ; szló ; Knoll ; Bertha
• 关键词：(&minus ; )-Deprenyl ; Deprenyl enantiomers ; Amphetamine enantiomers ; Behavioural differences
• 刊名：Physiology and Behavior
• 出版年：1996
• 出版时间：August, 1996
• 年：1996
• 卷：60
• 期：2
• 页码：589-594
• 全文大小：620 K

文摘

Effects of deprenyl and amphetamine enantiomers on different behavioural patterns were compared. Whereas (+)-amphetamine in doses of 1-3 mg/kg SC, (−)-amphetamine, and (+)-deprenyl in doses of 5-20 mg/kg SC increased the locomotor activity and the time the animals displayed stereotyped head movement, enhanced the acquisition of conditioned avoidance responses, and developed positive place preference conditioning, (−)-deprenyl, even in as high a dose as 20 mg/kg SC, failed to show any amphetamine-type behavioural effect. The results provide further proof why (−)-deprenyl, in contrast to other members of the amphetamine family, can be considered as a safe drug.