Effect of CCL2 on BV2 microglial cell migration: Involvement of probable signaling pathways
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- 作者：Shambhunath Bose ; Sunyoung Kim ; Yeonsoo Oh ; Md. Moniruzzaman ; Gyeongjun Lee ; Jungsook Cho ; neuroph@dongguk.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：CCL2 ; CCR2 ; BV2 cells ; Migration ; Intracellular signaling pathways
- 刊名：Cytokine
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：81
- 期：Complete
- 页码：39-49
- 全文大小：2855 K
文摘
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CCL2 induces migration of BV2 microglial cells.
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CCL2-induced signaling involves activation of MEK1/2, ERK1/2, and Akt in the cells.
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CCL2-induced activation of p90RSK is mediated through the MEK/ERK pathway.
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Akt, ERK1/2, and p90RSK are the downstream effectors of PI3K in CCL2 signaling.