Mono- and quadri-subtype virus-like particles (VLPs) containing H10 subtype elicit protective immunity to H10 influenza in a ferret challenge model
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- 作者：Peter Pushkoa ; ppushko@medigen-usa.com" class="auth_mail" title="E-mail the corresponding author ; Xiangjie Sunb ; Irina Tretyakovaa ; Rachmat Hidajata ; Joanna A. Pulit-Penalozab ; Jessica A. Belserb ; Taronna R. Mainesb ; Terrence M. Tumpeyb
- 关键词：Influenza ; Virus-like particles ; VLP ; H10N8 ; Recombinant vaccine ; Baculovirus
- 刊名：Vaccine
- 出版年：2016
- 出版时间：17 October 2016
- 年：2016
- 卷：34
- 期：44
- 页码：5235-5242
- 全文大小：1521 K
文摘
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H10 VLPs and Quadri-subtype H5/H7/H9/H10 VLPs were evaluated in a ferret H10 challenge model.
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Immunogenicity of VLPs was confirmed including serum HI antibody reactions with divergent HA subtypes.
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Both mono-subtype and quadri-subtype VLPs induced protection against heterologous H10N1 virus challenge.