Re-patterning of H3K27me3, H3K4me3 and DNA methylation during fibroblast conversion into induced cardiomyocytes
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- 作者：Ziqing Liu ; Olivia Chen ; Michael Zheng ; Li Wang ; Yang Zhou ; Chaoying Yin ; Jiandong Liu ; Li Qian ; li_qian@med.unc.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：iCM ; Epigenetics ; Reprogramming ; H3K4me3 ; H3K27me3 ; ChIP ; DNA methylation
- 刊名：Stem Cell Research
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：16
- 期：2
- 页码：507-518
- 全文大小：1940 K
文摘
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Cardiac transcription factor (TF) promoters are H3K4me +/H3K27me3 − in cardiomyocytes.
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Promoters of fibroblast-enriched TFs are H3K4me3 + AND H3K27me3 + in fibroblasts.
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↓ H3K27me3 ↑/H3K4me3 at cardiac promoters occurs early in iCM reprogramming (day 3).
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↑ H3K27me3 at fibroblast promoters occurs later in iCM reprogramming (day 10).
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Early rapid activation of cardiac fate/later progressive suppression of fibroblast fate