Increased interleukin-6 of skin and serum in amyotrophic lateral sclerosis

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• 作者：Ono ; Seiitsu ; Hu ; Jianguo ; Shimizu ; Natsue ; Imai ; Takashi ; Nakagawa ; Hachiro
• 关键词：Amyotrophic lateral sclerosis ; Cytokine ; Interleukin-6 ; Immunohistochemistry ; Skin ; Serum
• 刊名：Journal of the Neurological Sciences
• 出版年：2001
• 出版时间：June 15, 2001
• 年：2001
• 卷：187
• 期：1-2
• 页码：27-34
• 全文大小：169 K

文摘

Studies of skin in amyotrophic lateral sclerosis (ALS) have demonstrated morphological and biochemical alterations. Interleukin-6 (IL-6) has been suggested to have a trophic effect in nerve cells and to have a direct pathogenic role in neurodegenerative central nervous system (CNS) disorders. However, little is known concerning IL-6 in ALS patients. We examined IL-6 immunoreactivity of biopsy specimens of skin and measured serum IL-6 levels from 11 ALS patients and 11 diseased control subjects. IL-6 immunoreactivity was markedly positive in the epidermis and dermal blood vessels and glands and was moderately positive in the reticular dermis in all ALS patients. These optical densities for IL-6 immunoreactivity in ALS patients were significantly higher than in control subjects, and were significantly increased with duration of illness. Serum IL-6 levels were detected in 8 (73 % ) of 11 ALS patients compared with only 1 (9 % ) of 11 diseased control subjects. Serum IL-6 levels were significantly correlated with duration of illness in ALS patients and immunoreactivity of IL-6 of the epidermis. These data suggest that the increased levels of serum IL-6 may reflect an increased IL-6 immunoreactivity of skin in ALS patients.