Inflammatory markers in pediatric stroke: An attempt to better understanding the pathophysiology
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- 作者：Sarah E. Buerkia ; h ; sarah.buerki@cw.bc.ca" class="auth_mail" title="E-mail the corresponding author ; Denis Grandgirardb ; Alexandre N. Dattac ; Annette Hackenbergd ; Florence Martine ; Thomas Schmitt-Mechelkef ; Stephen L. Leibb ; g ; Maja Steinlinh ; on behalf of the Swiss Neuropediatric Stroke Registry Study Group
- 关键词：Arterial ischemic stroke ; Pediatrics ; Inflammation ; Biomarker ; Metalloproteinases
- 刊名：European Journal of Paediatric Neurology
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：20
- 期：2
- 页码：252-260
- 全文大小：966 K
文摘
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A possible inflammatory pathophysiology has been suspected in pediatric arterial ischemic stroke.
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This pilot study supports the assumption of an inflammatory process in pediatric and neonatal arterial ischemic stroke.
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Children and neonates with arterial ischemic stroke showed a significant up-regulation of metalloproteinases.
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Children and neonates had a different inflammatory pattern of circulating pro-inflammatory cytokines in plasma.